Hepathology and Organ Transplantation Unit

Liver is one of the largest and most important organs in the body. It weighs about three pounds in the average-sized person. It is reddish-brown, located on the right side of the abdomen behind the lower ribs, and the ribs help to protect the liver.

There are many types of liver diseases which can be hereditary, contracted from a virus, contracted as a result of excessive use of substances like alcohol or of being overweight.

It is well known that high alcohol consumption can result in liver damage. However, non-alcoholic fatty liver disease (NAFLD), predominantly caused by obesity, is now the leading cause of chronic liver failure. Fatty liver disease can progress until it develops into liver cancer.

Several liver diseases, including cirrhosis and fibrosis of the liver - where scar tissue slowly replaces normal, functioning liver tissue - lead to liver damage or liver failure.

Our highly-skilled and reputed team, supported by the most up-to-date equipment, work with other specialist teams across the IAH to provide liver treatment services.


  • Biliary, metastatic and pancreatic cancer
  • Genetic liver conditions
  • Liver biopsies and endoscopes
  • Gallstone treatment
  • Hepatitis treatment and support
  • Alcohol treatment and support.
  • Viral hepatitis
  • Fatty liver
  • Autoimmune liver diseases
  • Cholestatic liver diseases
  • Congenital liver diseases
  • Cirrhosis and complications
  • Portal hypertension (ascites, encephalopathy, varices etc.)
  • Liver cancer and many others are managed within our facilities. Yet, if needed, we bridge with outside services not available locally like TIPS, TACE or TARE, or a liver transplant. 

​​ Unit Leadership

Prof. Rifat Safadi

Professor Safadi is currently the Consultant of Liver Diseases and Organ Transplantation at Istishari Arab Hospital.

Professor Safadi is a Professor in Medicine at the Faculty of Medicine at Hadassah University Hospital in Jerusalem and a visiting scholar at the division of Liver Diseases at Mount Sinai School of Medicine in New York. He is also the Chairman of the Israeli Association for the Study of the Liver (2013 - 2016).

Professor Safadi is a member of several international liver association committees such as EASL (Scientific Committee and Governing Board (2007 - 2010) and AASLD (International Relations Advisory Committee 2010 - 2012). Since 2011, he has been the Director of the Liver Unit at the Institute of Gastroenterology and Liver Diseases, Division of Medicine in Hadassah, Ein-Karem. Additionally, he is the Director of the Liver Unit & Clinical Research Center (since 1998), at the Holy Family Hospital in Nazareth, Israel.

Prof. Safadi had his residency in Internal Medicine & Gastroenterology at Hadassah University Hospital in Jerusalem. His clinical focus includes viral hepatitis, cirrhosis complications, liver cancer, immune diseases of the liver and liver transplantation. With his laboratory team, his interplay research between lymphocyte subsets and hepatic fibrogenesis uncovered novel pathways and challenges. He received many awards and research grants and published more than 160 manuscripts in high rated professional journals within the clinical and basic research liver fields. He is also a reviewer and a member for editorial boards of several academic journals.

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